This oil on canvas depicts the Virgin Mary holding the Christ Child, flanked by Saint Sixtus and Saint Barbara, with two iconic cherubs below. Commissioned by Pope Julius II for the church of San Sisto in Piacenza, Italy, the painting exemplifies High Renaissance art with its balanced composition and emotional depth. Renowned for its divine beauty and tender expressions, it is now housed in the Gemäldegalerie Alte Meister in Dresden, Germany.
